The Licaps^® Drug Delivery System is a unique compilation of services and products that utilize lipid-based and semi-solid formulations to overcome common industry challenges and deliver cost-effective drugs. Unlike other options offered in the market, Capsugel's system is flexible and can be precisely tailored to achieve each client's specific objectives.

• Take advantage of Capsugel's contract research, scale-up and manufacturing services for a complete turn-key solution
• Manage development in-house utilizing our patented products, innovative machines and unique technology platforms
• Manufacture finished products in-house, or outsource with the experts at Capsugel

Capsugel's Licaps Drug Delivery System helps pharmaceutical companies achieve

• Improved bioavailability, particularly for poorly water soluble compounds
• Formulation of compounds with low melting points and low dose/high potency attributes
• Safer containment for high potency compounds
• Faster time-to-market due to less complex formulation and development processes
• Superior product integrity with secure capsule sealing of liquid fills and powder filled capsules
• Flexible outsourcing options from research services to commercial manufacturing
• In-house development and manufacturing
• Ease of scale-up and validation
• Unique trade dress possibilities

For more information on how our Licaps Drug Delivery System can help you, Contact Us.

Discovering viable and profitable pharmaceutical products today often requires working with NCE's that are poorly water soluble. These NCE's may require time-consuming experimentation and analysis in order to achieve satisfactory drug absorption from a traditional solid oral dosage form – a challenge that can sometimes seem insurmountable. However by formulating in oil-based liquid or semi-solid formats, bioavailability may be significantly improved and API content uniformity can be improved, particularly at low dosage levels.

Helping achieve these formulation goals for poorly water soluble compounds is a key initiative at Capsugel, and to address this critical need we created a dedicated Pharmaceutical Research and Development Center. This state-of-the-art facility offers a full range of services, from pre-clinical development services to commercial manufacturing, and is staffed by scientists who have a unique insight into lipid-based oral drug delivery.

For more information, Contact Us.

 

Licaps^® capsules, created specifically for our Licaps Drug Delivery System, are specialized two-piece capsules for liquid and semi-solid formulations. Available in both gelatin and HPMC, Licaps capsules are used in our R&D liquid filling and sealing machine (CFS 1200) and our commercial-scale sealing machine to produce a robust dosage form without banding.

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Utilizing our patented LEMS (Liquid Encapsulation Microspray Sealing) technology, Capsugel has developed both an R&D benchtop liquid filling and sealing machine for clinical trial batches and a commercial-scale sealing machine.

To learn more about our commercial-scale sealing equipment,
please contact your local Sales Representative.

Upon successful development of a client’s liquid formulation, Capsugel offers the services and patented technology to assist clients with clinical batches up to full-scale production. Small-scale clinical trial batches for Phase I can be created by Capsugel incorporating various analytical activities, including:

• cGMP analytical development and validation
• Specification development
• ICH regulatory stability studies
• Cleaning method development and validation

Once Phase I trails are completed, Capsugel can assist clients with Phase II & III clinical activities, including:

• Formulation optimization to enhance manufacturing process or stability
• Continued analytical development and transfer of methods
• Technology transfer support
• Scale-up to commercial scale manufacturing equipment

For more information, Contact Us

Capsugel offers manufacturing options to suit practically any client need. Contract commercial manufacturing is available for drugs formulated by our Global Pharmaceutical Research and Development Center or customer-developed liquid formulations. And for customers wishing to do in-house manufacturing, Capsugel offers the specialized equipment, products and expertise needed to get the job done effectively. For more information, Contact Us