Pharmaceutical Applications

Vcaps^® capsules are the perfect choice for pharmaceutical applications when a non-animal capsule is required. Composed of hypromellose (HPMC), they offer numerous and unique benefits as a dosage form.

Resistant to Capsule Cross-Linking
Hypromellose is a well-characterized and stable material. It will not cross-link with aldehydes and other reactants that commonly cross-link with gelatin, causing insolubilization with gelatin capsules.

Excellent Machinability
Vcaps capsules dimensions are identical to those of gelatin capsules and machinability tests have been successfully conducted with major CFM manufacturers.

pH Independent Dissolution
In vitro studies with acetaminophen closely match the dissolution profile of gelatin across the entire pH range.

Well Suited for Moisture-Sensitive Drugs
A low moisture content ensures stability with hygroscopic fills and NCEs that can be negatively affected by moisture.

Compatible with All Major Excipients
Excipients such as lactose, maize starch, sorbitol, magnesium stearate, pre-gelatinized starch, microcrystalline cellulose and carboxymethylcellulose are all compatible with Vcaps capsules.

Excellent for Modified Release Coatings
The shell texture of Vcaps capsules enables good adhesion and coating uniformity using aqueous systems.

Meets the Requirements and Preferences of the Entire Development Team
Formulators: require a non-cross-linking capsule that is well characterized, compatible with current excipients and assays, and has a gelatin-like dissolution.
Marketing: prefers a capsule that meets the dietary and cultural needs of patients.
Manufacturing: needs a capsule with gelatin-like performance that can run on existing filling equipment.
Regulatory: wants a capsule polymer that has a proven safety record and wide regulatory acceptance.
Clinicians: need to be certain that patient compliance is assured.

For more information on Vcaps^® capsules contact a Capsugel Representative.